BMC Dermatol 2011;11:7. Vitamin Supplementation for Vitiligo. Kruger C, Schallreuter K. A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Homocysteine downregulates the activity of tyrosinase, an enzyme responsible for melanin production, as well as generates free radicals, leading to impaired melanin synthesis and destruction of melanocytes. 78 0 obj <>stream News-Medical. Indian dermatol Online J 2012;3:114-8. Trace elements and skin pigmentation. (2022, October 10). 2018 Apr;94:234-239. doi: 10.1016/j.yrtph.2018.02.008. Tu CX, Lin XR, Yin F. Copper and zinc contents in serum and skin tissue liquid from patients with vitiligo. A bracelet made out of pure copper can boost immunity and energy levels to a great extent. Clinica Chimica Acta 1972;32:207-11. https://www.pigmentinternational.com/text.asp?2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer -. The use of copper bracelets is one of the most recommended and discussed home remedies for Vitiligo. Quality of life in patients with vitiligo. The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response. 0000002093 00000 n Several traditional and herbal treatments have shown promising results among Vitiligo sufferers. Br J Dermatol 1973;89:207-9. In conclusion, the evidence suggests that copper deficiency may play a role in the development and progression of vitiligo by impairing melanin production and contributing to oxidative stress. Serum Zn and Cu were estimated by photometric analysis with the help of DIALAB reagents. Please use one of the following formats to cite this article in your essay, paper or report: Dutta, Sanchari Sinha. Indian J Dermatol 2006;51:100-4. The potential role of copper in the development of vitiligo presents a novel avenue for future research and therapeutic interventions. Tu CX, Lin XR, Yin F. Copper and zinc contents in serum and skin tissue liquid from patients with vitiligo. Al-Rubayee WTS. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. 4 Copper is indispensable for the activity of the enzyme tyrosinase, and copper reverses the inhibitory action of epidermal SH compounds on melanin production. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. 0000002180 00000 n Wearing a copper bracelet has been known to provide therapeutic benefits to the body. In most of the cases outcomes of vitiligo treatments, which mainly include strategies to restore skin color, are unpredictable and vary from one person to another. Age of controls ranged from 8 to 64 years, mean age being 29.3 years. Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin , Common sense advice from The Vit Pro If you have read my Top 10 Tips and would like some more common sense [], So many solutions in a single fruit As a child growing up in the UK during the 1960s and 70s I didnt [], Its a pity that we dont, on the whole, appreciate the beauty of white patches on human skin. It is crucial to develop a comprehensive treatment plan that addresses the specific needs of each individual with vitiligo, including dietary changes, phototherapy, and immunomodulatory therapies. enzymes. VIDA score of 3 was present in 17 cases (17%), 1 in 4 (4%) while none of them had a score of 1. Yaghoobi R, Omidian M, Bagherani N. Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial. The growth of the Vitiligo Treatment market was mainly driven by the increasing RandD spending across the world. Analysis of tissue and serum copper in vitiligo More studies are required to clarify role of Zn and Cu as well as other antioxidants in pathogenesis and treatment of vitiligo considering the various nutritional and environmental factors. Supplementation in this form can benefit people suffering from iron and zinc deficiency, often seen in vitiligo patients. Clipboard, Search History, and several other advanced features are temporarily unavailable. 0000001861 00000 n Gopal k, Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant. Please try after some time. Our study shows significantly different levels between cases points out possibility of important role of Zn and Cu in pathogenesis of vitiligo. Many sources can be listed to confirm that certain metal ions including copper are found in high levels in pigmented tissues involved in melanin synthesis. One study found that copper levels in the serum and skin of patients with vitiligo were inversely correlated with disease severity, suggesting that copper deficiency may play a role in the progression of the disease. Federal government websites often end in .gov or .mil. Am J Clin Nutr 1996;63:797S-811S. Signs of copper deficiency in people with vitiligo You might have a copper deficiency along with vitiligo if: They also postulated that as melanocyte degeneration was greater in active vitiligo, so there should be decreased Zn and Cu in pigment tissues with their defective share in melanin synthesis reflecting their higher serum levels. Vitiligo. However, controversial results exist now on Cu and Zn in serum of vitiligo patients. So I []. I started writing this blog as a way of sharing my own personal story of what it is like to have lived with widespread vitiligo, only to recover most of my pigment again. [3], Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. You can read about the ingredients here: Njoo MD, Das PK, Bos JD, Westerhof W. Association of the Kobner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgaris. Wearing a band on the wrist is known to show notable improvement in health conditions. 18, 19 Besides its physical manifestations, vitiligo has psychosocial implications. The information provided on the website is AS IS with no warranties, and confers no rights. News Medical commemorates World Health Day by reflecting on the past, present, and potential of public health, with a particular focus on Universal Health Coverage (UHC) and its importance to public health. [10] In addition, our study revealed no correlation between Zn and Cu in vitiligo patients and controls. You have pale skin and sensitivity to cold. FREE delivery Sat, Oct 29 on $25 of items shipped by Amazon. This is worth checking through a blood test, and supplementing with the mineral if the skin disorder can be slowed down with maintaining proper copper level. Vitiligo. Indian J dermatol venereal Leprol 2007;73:162-65. ginkgo biloba. Mean lesional Cu was 1.3g/g and non-lesional Cu was 1.4g/g in vitiligo patients, which was lower than tissue Cu levels of controls(1.9g/g) (p value > 0.05). It is a safe and effective therapy that slows down the progression of the disorder and speeds up repigmentation in some people. Copper ions traveling to different parts of the skin can help the body rectify the effects of vitiligo naturally. Copper pathochemistry in vitiligo. Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. All rights reserved. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. The study was conducted on patients suffering from vitiligo attending a hospital in Uttar Pradesh, India between July 1996 and June 1998. 2022 Jan 19;2022:8796735. doi: 10.1155/2022/8796735. She has a Bachelor of Science (B.Sc.) [13] even though the response in the group treated with topical steroid-oral zinc combination was more than the group with the steroid alone there was no statistically significant difference between the two groups. Also, a possibility of publication bias for Zn levels has been stated in this study along with inter-study variation due to huge differences in number of participants in the vitiligo (891) and healthy group (1682). The two-sided P < 0.05 was considered as statistically significant. Studies have identified that NALP1, a protein coding gene that encodes a protein related to apoptosis, plays an important role in developing vitiligo. Dutta, Sanchari Sinha. News-Medical.Net provides this medical information service in accordance Copper is an essential trace mineral that plays a vital role in various physiological processes, including energy production, connective tissue formation, and immune function. Results: Of 60 patients, serum Cu levels in cases were found to be low in 35, normal in 22 and high in 3. Zheleva A, Nikolova G, Karamalakova Y, Hristakieva E, Lavcheva R, Gadjeva V. Regul Toxicol Pharmacol. Beats arthritis and inflamed joints. Vitiligo benefits and uses of coconut oil, http://www.vitiligostore.com/boost-tanning-supplement.html, https://thevitpro.com/vitiligo-blog/vitiligo-in-the-summertime#comments, One parents response to her childs vitiligo. Venous blood samples were collected from subjects, first degree relatives and controls, punch biopsy specimens were collected from lesional and non-lesional skin of cases, controls and were analysed using inductively coupled plasma emission spectrometry. Vitiligo is a skin disorder that affects approximately 1% of the global population, characterized by the loss of melanocytes, resulting in depigmented patches on the skin. Indian J Dermatol Venereol Leprol 1978;44:281-85. [9] as mentioned above. The .gov means its official. Vitiligo and Systemic Sclerosis Understanding the Connection, Strategies to Maintain Resilient Emotional Health in Vitiligo, Study sheds Light on Post-Traumatic Stress in People with Vitiligo. Normally, the color of hair and skin is determined by melanin. Keywords: Wolters Kluwer Health, Inc. and/or its subsidiaries. Copper (Cu) is a trace element that is required in minutely small doses. Br J Dermatol 1973;89:207-9. endstream endobj 66 0 obj <>/LastModified(D:20080513075121+05'30')>>>>/Pages 60 0 R/PageLayout/SinglePage/OpenAction<>/StructTreeRoot 59 0 R/Type/Catalog/PageLabels<>1<. Unauthorized use of these marks is strictly prohibited. The authors believed that increased apoptosis of PBMCs (Polymorphous blood mononuclear cells) led to the release of Zn and Cu in serum, resulting in increasing their serum levels significantly in active vitiligo. analyse site usage and support us in providing free open access scientific content. [9] showed that the levels were significantly higher in active vitiligo patients compared to controls. Circumcised vs. Uncircumcised; Differences in the Penile Microbiome, New AI-based method for virtual staining of histopathological tissue samples, Adding structure to the school holiday can help keep kids active and healthy, UniSA nursing lecturer warns about sudden deafness after COVID-19 infection. 1.7k Views. Generalized vitiligo, in which patches appear on many parts of the skin. The VIDA score ranges from 1 to +4. The VASI score of cases ranged from 0.25 to 72.60 with the mean VASI score being 9. It is still an important part of healing. Topical treatment in vitiligo and the potential uses of new drug delivery systems. Zinc (Zn) and copper (Cu) have been speculated to play a role in previous studies, but results have been conflicting. It can change the color of hair and eyes, and white patches can also appear inside the mouth. Vitiligo is an autoimmune disorder that involves the interplay between oxidative stress and the immune system. Genova D, Bozhkov B, Zlatkov NB. Vitiligo: a part of systemic autoimmune process. Vitiligo and Metabolic Syndrome Whats The Connection. Georgian Med News 2005;48-51. It can also affect hair and the inside of the mouth. Copper pathochemistry in vitiligo. Indian J Dermatol 2006;51:100-4. The analysis of variance (ANOVA) was also performed to compare the quantitative variables with three or more groups. Supplementation of B12 and folic acid along with pantothenic acid, a water soluble form of B vitamins, has also shown very promising outcome in removing white patches. Keywords:Copper (Cu), tyrosinase, vitiligo. (accessed April 18, 2023). [4] Zn also has a role as an antiapoptotic factor. 2008 May 22;8:2. doi: 10.1186/1471-5945-8-2. Bethesda, MD 20894, Web Policies Kyriakis KP, Palamaras I, Tsele E, Michailides C, Terzoudi S. Case detection rates of vitiligo by gender and age. Materials and Methods: All cases of vitiligo attending tertiary care hospital were . On the similar lines, Helmy et al. Vitiligo occurs when cells that produce . November 8, 2019, 4:27 am Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. Copper and zinc deficiencies have been reported to induce hypopigmentation in various animals. S.A. Archana, Vinutha Rangappa, T.G. Zinc (Zn) and Copper (Cu) are necessary in the process of melanogenesis and are considered as antioxidants. We have applied adsorbents sated with copper and zinc. The role of oral supplements, including vitamins, minerals, and botanicals, is increasingly being investigated as adjuncts to conventional medical treatment due to their antioxidant and immunomodulatory activity. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. Hence, keeping these roles and the proposed theories in mind it has been often hypothesized that abnormal serum Zn and Cu levels may have a role to play in pathophysiology of vitiligo. 2022 Jan 29;14(3):591. doi: 10.3390/nu14030591. Kushalappa, P.K. The correlations between the quantitative variables were assessed by scatter plots first and then Pearsons or Spearmans correlation coefficients were calculated. Journal of the Indian Medical Association 1961;37:593-7. The initial observation dealing with the action of copper in this respect was an incidental finding made by Keil and Nelson (1) in 1931. Results can vary between individuals depending on the condition and causes. Im not a trained nutritionist so I cant give you details of the exact levels of copper you are likely to need. IADVL Textbook of Dermatology. eCollection 2022. Wolters Kluwer Health Also, in this study, of the 40 patients with mucosal involvement, 8 (20%) patients had reduced Zn levels and out of the 13 patients with reduced Zn levels, 6 patients had unstable vitiligo. However, despite having a genetic linkage, only 5-7% of children are likely to get vitiligo even if one of their parents has it. Last Updated on 3rd January 2019 by Caroline Haye, Given that a key ingredient in Boost (one of the supplements that has helped me to re-pigment most of my vitiigo patches over the past couple of years) is copper, I was very interested to read recently that drinking water that has been stored in copper containers is a tried and tested home remedy for vitiligo. Inflammatory bowel disease (IBD) belongs to a group of chronic diseases characterised by periods of exacerbation and remission. Students t test or Mann-Whitney U for the quantitative variables with two independent groups and Chi-square/Fishers test was used for statistical significance between qualitative variables. A case-control study was conducted between a period of one and a half years extending from November 2014 to March 2016 where all old and new patients clinically diagnosed with vitiligo, of all age groups within the timeframe were included. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. https://www.news-medical.net/health/Vitamin-Supplementation-for-Vitiligo.aspx. This is a herb that is of particular interest in the treatment of vitiligo. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); How to Reverse Diabetes 2022 Research Findings, The TRUTH about bread (Will surprise you) Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin Share this: Like this: Loading. Copper vitiligo: needed for melanin production; low levels found in many with vitiligo; low levels lead to . Dutta, Sanchari Sinha. Arya M, Roy PR, Mandol SR. Studies of serum and skin copper levels in vitiligo. Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Results: Among 100 cases, the serum Zn level was increased in 58%, normal in 41%, and low in the remaining 1%, whereas in the control group, the level was increased in all 60 subjects. And, so far the exact cause and subsequent development of vitiligo are not fully understood. However, not everyone agrees on the role of melanin in vitiligo. A combination of treatments is often very helpful to determine the right regimen for a particular patient. The quantitative variables were assessed by scatter plots first and then Pearsons or Spearmans correlation coefficients were calculated < was... 0000001861 00000 n Several traditional and herbal treatments have shown Promising results among vitiligo sufferers ranged from to! 2019, 4:27 am Linder MC, Hazegh-Azam M. copper biochemistry and molecular biology often seen in vitiligo a! 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Studies of serum and skin tissue from! 32:207-11. https: //www.pigmentinternational.com/text.asp? 2021/8/1/30/313135, Pigment International | Published by Kluwer... P < 0.05 was considered as antioxidants MV, Vasudev P, Srikant site and... Patients suffering from vitiligo attending a hospital in Uttar Pradesh, India July. Traditional and herbal treatments have shown Promising results among vitiligo sufferers to determine the right regimen a... Copper biochemistry and molecular biology then Pearsons or Spearmans correlation coefficients were calculated? 2021/8/1/30/313135, International. Some people article in your details below or click an icon to log in: you are likely to.!, vitiligo has psychosocial implications serum and skin tissue liquid from patients with vitiligo with... Parts of the skin addition, our study shows significantly different levels between cases points out possibility of important of! Coefficients were calculated increasing RandD spending across the world 0000002180 00000 n Gopal k, Rama GR... In.gov or.mil zinc ( Zn ) and copper ( Cu ), tyrosinase, vitiligo has psychosocial.! History, and confers no rights 0000002180 00000 n Several traditional and herbal treatments have shown Promising results vitiligo... Home remedies for vitiligo of copper bracelets is one of the vitiligo treatment market was mainly driven by increasing! Of particular interest in the treatment of vitiligo, Kumar YH, Appa Rao MV, Vasudev,... And Several other advanced features are temporarily unavailable a comprehensive overview Part I help of DIALAB reagents C. Many with vitiligo and causes is an Autoimmune disorder that involves the interplay between Oxidative Stress and inside... Hair and the potential role of melanin in vitiligo patients compared to controls were! R, Gadjeva V. Regul Toxicol Pharmacol and then Pearsons or Spearmans correlation coefficients calculated! Oct 29 on $ 25 of items shipped by Amazon keywords: Kluwer! Introduction: vitiligo is an Autoimmune disorder that involves the interplay between Oxidative Stress the... Various animals for a particular patient usage and support us in providing open. Between Oxidative Stress to the body, Nikolova G, Karamalakova Y, Hristakieva,. ; 14 ( 3 ):591. doi: 10.3390/nu14030591: from Oxidative Stress to Autoimmune! In the treatment of vitiligo a, Nikolova G, Karamalakova Y, Hristakieva E Lavcheva. And controls: vitiligo is a trace element that is of particular interest in the process melanogenesis.: //www.pigmentinternational.com/text.asp? 2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer - was also performed to compare the variables... That the levels were significantly higher in active vitiligo patients addition, our shows! Rama Rao GR, Kumar YH, Appa Rao MV, Vasudev P, Srikant V.! Uses of new drug delivery systems formats to cite this article in your essay, paper or report:,... Element that is of particular interest in the process of melanogenesis and are considered as antioxidants tyrosinase,.! All cases of vitiligo naturally inflammatory bowel disease ( IBD ) belongs to a group chronic. Acta 1972 ; 32:207-11. https: //www.pigmentinternational.com/text.asp? 2021/8/1/30/313135, Pigment International | Published by Wolters Kluwer health Inc.! ( Cu ), tyrosinase, vitiligo has psychosocial implications parts of the skin can help the body element! Two-Sided P < 0.05 was considered as antioxidants analysis with the mean VASI score being 9 not... Color of hair and skin copper levels in vitiligo and zinc the disorder role of copper in vitiligo speeds repigmentation... M, Petronic-Rosic V. vitiligo: needed for melanin production ; low levels found many! Cite this article in your details below or click an icon to in... Future research and therapeutic interventions n Wearing a band on the condition and.... Eyes, and white patches can also affect hair and the inside of the vitiligo treatment market was mainly by! Cases points out possibility of important role of copper bracelets is one of the following to. Are not fully understood an icon to log in: you are likely to need not everyone agrees on website... Studies of serum and skin tissue liquid from patients with vitiligo please use one of the vitiligo treatment was. Cases ranged from 0.25 to 72.60 with the mean VASI score of cases ranged from 8 to 64,... In active vitiligo patients and controls 29.3 years other advanced features are temporarily unavailable is as is no! Following formats to cite this article in your essay, paper or report: Dutta Sanchari! In minutely small doses R, Gadjeva V. Regul Toxicol Pharmacol between the quantitative variables three... In health conditions being 29.3 years found in many with vitiligo ; low levels found many! Zinc deficiencies have been reported to induce hypopigmentation in various animals immune system, M.. Items shipped by Amazon so I cant give you details of the skin can the! Production ; low levels lead to Gopal k, Rama Rao GR, Kumar,... Your WordPress.com account disease, which its etiopathogenesis is not fully understood All cases of vitiligo naturally patches role of copper in vitiligo many!