View abstract. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. 11-15-2009;171(1-3):508-513. root of Scutellaria baicalensis Georgi. Planta Med 2000;66(8):694-698. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. These medications include atorvastatin (Lipitor), cerivastatin (Baycol), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and simvastatin (Zocor). View abstract. What Are The Several Uses Of This Medicinal Herb? Broncel, M. [Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi]. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. View abstract. Nutr Cancer 2004;49(2):217-22. Pharm Biol 2011;49(3):256-261. View abstract. Int Immunopharmacol 2014;23(2):558-67. Polysaccharides in S. barbata demonstrate antioxidant and free radical-scavenging activity(15). Numerous traditional uses of Scutellaria baicalensis have been confirmed by current investigations. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. View abstract. View abstract. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. Baikal skullcap might slow blood clotting. 6-29-2011; View abstract. View abstract. New York, NY: CRC Press LLC. View abstract. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. J Altern Complement Med 2002;8(5):567-572. Biomed Res Int 2016;2016:5697571. There have been reports of fever and lung inflammation in people who took Baikal skullcap. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. The root is used to make medicine. J Ethnopharmacol. View abstract. View abstract. View abstract. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. 2-25-2009;122(1):20-27. Heo, H., Shin, Y., Cho, W., Choi, Y., Kim, H., and Kwon, Y. K. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. The pharmacology of Chinese herbs. Zhang H and Huang J. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. US Food and Drug Administration (FDA). View abstract. Contact Dermatitis. Biull.Eksp.Biol Med 1999;128(9):327-329. View abstract. View abstract. View abstract. Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Shang, Y. There have been reports of fever and lung Studies on inhibitors of skin tumor promotion. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Int J Oncol. NIH National Cancer Institute. View abstract. 11-1-2009;284(2):198-207. Taking large amounts of Baikal skullcap along with alcohol might cause too much sleepiness. Seattle, WA: Eastland Press 1996:107-8. Drug Metab Dispos 2005;33:537-46. 1990;36(5):602-607. It is often used in combination with other herbs. Some medications, called sedatives, can also cause sleepiness and slowed breathing. View abstract. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, Kaplya, O. 7-1-2005;382(1-2):71-75. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Statements made about products have not been evaluated by the Food and Drug Administration. Baicalin also activated caspase-3, resulting in apoptosis of leukemia-derived T cells. In that case, it is either used for hormone synthesis or hormone breakdown, including estrogen and testosterone, which are not advised to combine with the Chinese herb. Zhang S, Cheng Z, Huang B, and Li J. View abstract. View abstract. Fan L, Zhang W, Guo D, et al. Planta Med 2000;66:91-3. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. View abstract. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Call a physician if symptoms develop or persist. Keep in mind that natural products are not always necessarily safe and dosages can be important. View abstract. View abstract. Zhou, X., Zhang, Q., Liang, H., Jiang, Y., Wang, X., Wang, B., and Zhao, Y. View abstract. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. J Med Chem 10-21-2004;47(22):5555-5566. View abstract. Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Eur J Pharmacol 4-24-2006;536(1-2):192-199. Nutr Res 2009;29:298-304. Please do not use SMS English, Short Text and Words like hi, hello. J Chem Ecol. Biological properties of baicalein in cardiovascular system. 2007;56(6):280-283. Lee, C. Y., Wang, J. Y., Chen, T. C., Jiang, J. K., Peng, C. H., Kuo, C. D., Chang, W. C., Chiu, J. H., and Wu, C. W. Effects of S/B remedy containing Scutellaria baicalensis and Bupleurum scorzonerifolfium on hepatic interleukin-6 related signal transducer and activator of transcription 3 activation in mice through cell-cell interaction. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. View abstract. Pulm.Pharmacol Ther 2010;23(5):411-419. Diabetes medications are also used to lower blood sugar. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Nat Prod 1998;61:1413-5. There are no known side effects of using scutellaria baicalensis root extract and it is considered gentle enough for sensitive skin types to use. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. A., Han, D. Y., and Kim, G. S. Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Neuroprotective effects of flavonoids were ameliorated by diazepam, a GABA receptor agonist, suggesting that the components influence GABA receptor activity(5). Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. It can cause drowsiness, fever, lung inflammation, and other information Baikal skullcap might cause sleepiness and drowsiness. View abstract. Diabetes: Baikal skullcap can affect blood sugar levels in people with diabetes. View abstract. View abstract. 1999;385-6, 400-1. Ai.Zheng. Biochim Biophys Acta 1999;1472:643-50. Gol'dberg VE, Ryzhakov VM, Matiash MG, et al. Scutellaria baicalensis is a very well-known anti-inflammatory agent widely used in oriental medicine. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Ong, E. S., Len, S. M., and Lee, A. C. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. [Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria]. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. View abstract. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. Allergic contact dermatitis to Tinosorb S, Scutellaria baicalensis, and other emerging allergens in cosmetics. Flavonoids and scutebarbatines can regulate immune function, with decreases in IL-17, IL-10, FOXP3, TGF-beta1, RORgammat, and IL-6 levels, and increases in IL-2 and IFN-gamma levels(23). The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. Phytomedicine. Immunobiology 2006;211(5):359-368. Thanks to its salicin content, willow bark is often touted as From diagnosis to treatment, our experts provide the care and support you need, when you need it. Clin Pharmacol Ther 2007;82:726-33. Talk with your healthcare provider before using Baikal skullcap if you are taking medications used for lowering cholesterol. View abstract. Hao, H., Aixia, Y., Lei, F., Nancai, Y., and Wen, S. Effects of baicalin on Chlamydia trachomatis infection in vitro. 1995;15(8):465-467. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. J Med Food 2009;12:1143-8. View abstract. 2021 Mar;10(3):2979-2989. Case ReportsAcute liver injury: In patients with arthritis, following consumption of a formula containing baicalin derived from S. baicalensis or Chinese skullcap. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. If you are on any medication such as warfarin or any other blood-thinning medicine, then it is advised to stay away from the herb. Zhongguo Zhong.Yao Za Zhi 2007;32(17):1827-1829. View abstract. J Ethnopharmacol. Br J Pharmacol 2009;157:1410-18. View abstract. International Journal of Pharmacology 2010;6(2):81-88. Clin Pharmacol Ther 2007;83:471-6. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. View abstract. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Therefore, if you are a diabetic patient, you should stay away from such herbs. View abstract. Huang, W. M., Yan, J., and Xu, J. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. View abstract. 5-24-2006;105(3):346-351. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Eksp Klin Farmakol 1997;60:28-30. Dygai, A. M., Suslov, N. I., Skurikhin, E. G., Churin, A. Make an infusion of Scutellaria Macrantha root. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. Przegl.Lek. Ann Intern Med 2012;156:857-60. Eksp.Klin Farmakol. Clin Pharmacol Ther 2007;83:471-6. Blach-Olszewska, Z., Jatczak, B., Rak, A., Lorenc, M., Gulanowski, B., Drobna, A., and Lamer-Zarawska, E. Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones. View abstract. Cell Mol Biol Res 1993;39(2):119-124. 2011;39(1):217-224. View abstract. This will help them manage your care and keep you safe. Shurygin, A. Y., Bezzubov, N. V., Ignatova, E. A., Nikolaev, S. M., and Viktorov, I. V. Baikal skullcap extract stimulates neurite growth in cultures of rat dorsal root Ganglia. WebScutellaria Baicalensis Extract. View abstract. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. The total content of these 6 main flavonoids account ed for 68.5% of the extract . Bioorg.Med Chem 8-1-2008;16(15):7516-7524. Altavilla D, Squadrito F, Bitto A, et al. View abstract. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. Clin Transl Sci 2021;14(5):2017-2024. Pharmacogenomics of human OATP transporters. View abstract. Pursuing basic and translational research across 9 programs and 100+ labs, Focusing on clinical cancer research and population health, Bridging the lab and the clinic through translational research, Fostering interdisciplinary collaborations between laboratory scientists and clinicians, Partnering with other academic and research institutions, Offering state-of-the-art resources for our researchers, Offering a curriculum with a focus on cancer, Connecting college seniors to future careers in biomedicine, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, Integrative Medicine at Home Membership Program. Zhongguo Zhong.Yao Za Zhi 2009;34(22):2910-2915. Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. WebBaicalin extracts have strong anti-inflammatory effects. Therefore, one should not take the herb on their own Rather; they should ask a doctor and go with a suitable preference for treating cancer. View abstract. Adv Ther 2010;27:731-42. A preliminary study of S. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes(23). View abstract. Hong, T., Jeong, M. L., Zahn, M., Fay, B. View abstract. You, C. L., Su, P. Q., and Zhou, X. X. BMC.Complement Altern Med 2006;6:27. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. 2019;133:109402. 1997;57(1):63-67. Planta Med 1998;64:571-2. Taking Baikal skullcap might decrease how well the body gets rid of lithium. Baikal skullcap might change how quickly the liver breaks down these medications. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. Am J Chin Med 2006;34(2):245-261. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. In liver tumors, S. barbata flavonoids suppressed angiogenesis via VEGF regulation, MMP2/9 inhibition, and increased TIMP1/2 expression(17)(29). Ye F, Wang H, Jiang S, et al. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. View abstract. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. 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